The effect of COVID-19 on college student mental health is widely reported and can, in part, be evidenced by the increasing demand for counseling services. The degree to which the pandemic affected substance use patterns, including binge drinking and cannabis use, appears to be less obvious and, perhaps, more complicated. We asked two national experts what the early data show on substance use patterns over the last two years and how we might interpret what we are seeing. Their answers include the identification of looming concerns and emerging best practices.