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In 1986, the shocking death of the greatest basketball player who never played professional basketball, Leonard “Len” Bias, shocked the nation. Len was a first-team All-American college basketball player from the University of Maryland and was a second overall pick of the Boston Celtics in the 1986 NBA draft. Tragically, Len died two days after the NBA draft from cocaine intoxication after ingesting an unusually pure dose of the drug. His death is referred to as the catalyst event that sparked passage of the Anti-Drug Abuse Act of 1986. We can clearly say the pretext for the field of drug prevention as a professional practice was the substance misuse of a young adult on a college campus. Yet, 33 years later, where are we with regard to college drug abuse prevention? What are some of the best strategies and approaches to address the current drug issues facing America’s college students?